Add time:09/09/2019 Source:sciencedirect.com
Synthesis of 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-one derivatives catalyzed by DODECYLBENZENESULFONIC ACID (cas 121-65-3) was carried out in 80–92% yields at 40–42 °C within 1–2 h in aqueous media via one-pot three-component condensation of isatoic anhydride, aromatic aldehyde and amine under ultrasound irradiation. Convenient work-up procedures, mild reaction conditions, avoiding the use of organic solvents, and friendly to environment are the salient features of this protocol.
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