Add time:09/07/2019 Source:sciencedirect.com
The ‘on-water’ generation of carbonyl ylide dipoles from diazoamides in the presence of rhodium(II) acetate dimer as the catalyst was demonstrated for the first time to synthesize spiroindolo-oxiranes and -dioxolanes. Unusual generation of carbonyl ylides with aromatic aldehydes having electron-withdrawing substituents and 1,3-dipolar cycloaddition reactions with aromatic aldehydes having electron-donating substituents were described in water with complete diastereoselectivity. This discovery provides an environmentally friendly way to generate carbonyl ylide dipoles and to synthesize substituted spiro-heterocycles in water with stereoselectivity, avoiding the use of toxic halogenated organic solvents.
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