Add time:09/09/2019 Source:sciencedirect.com
Eight tripeptides containing L-Phe-L-Tyr were synthesized, and their effects on the excitability of a giant neurone (tonically autoactive neurone, TAN), identified in the suboesophageal ganglion of an Africa giant snail (Archiatina fulic Férussac), were examined. Of these tripeptides, the following three showed a marked inhibitory effect: L-Glu-L-Phe-L-Tyr (most effective; critical concentration: 3 × 10−6 ∼ 10−5 M), Gly-L-Phe-L-Tyr and sarcosine-L-Phe-L-Tyr. The TAN inhibition caused by L-Glu-L-Phe-L-Tyr was not due to an increased membrane permeability to chloride ions.
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