Add time:09/05/2019 Source:sciencedirect.com
We report the synthesis of 5′-modified thymidines (16, 18, 21, 23) and 5,5′-bis-substituted 2′-deoxyuridine analogues (30, 47) as inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt). These analogues were evaluated for their capacity to inhibit TMPKmt and solely two 5′-modified thymidines were found to possess moderate inhibitory activity. In addition, a feasibility study of protecting groups for the 5-CH2OH moiety of 2′-deoxyuridines is described that enables to introduce the desired 5′-modification.
We also recommend Trading Suppliers and Manufacturers of 5-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one (cas 15771-06-9). Pls Click Website Link as below: cas 15771-06-9 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View