Add time:09/07/2019         Source:sciencedirect.com

Inclusion complexation between furnidipine (2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-tetrahydrofurfuryl 5-methyl diester), a calcium-channel antagonist, and β-cyclodextrin (β-CyD) was studied in aqueous solution by using both spectrophotometric and electrochemical measurements.The phase solubility profile was classified as AL-type, indicating the formation of 1:1 stoichiometric inclusion complex of furnidipine with β-CyD. Based on the spectrophotometric absorbance’s variations, a formation constant value, Kf, of 156 M−1 was determined.Electrochemical measurements using chronocoulometric experiments were used for the determination of the diffusion coefficients. In absence of β-CyD, a diffusion coefficient value of 4.32×10−6cm2s−1 was obtained for furnidipine. The addition of β-CyD produced a decrease of 30% for the diffusion coefficient.Formation of inclusion complexes of furnidipine with β-CyD was proved to increase more than three times the solubility of furnidipine.

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