Add time:09/26/2019 Source:sciencedirect.com
The thermodynamic quantities for the complex formation between the enantiomers of the β-blocking drug alprenolol and cellobiohydrolase I (CBH I), that earlier has been used as a chiral selector for aminoalcohols, revealed positive ΔH0 — values in all cases implying an entropy driven process. Association constants (Ka) for cellulase and the (R)- and (S)-enantiomers of alprenolol were determined by isothermal titration microcalorimetry and the inhibition constants (Ki) by enzyme inhibition experiments. Both inhibition experiments and microcalorimetry revealed that the affinity between the enantiomers of alprenolol and CBH I was higher in sodium phosphate buffer than in potassium phosphate buffer. This result was in agreement with previously reported liquid chromatographic separations of enantiomers using a chiral stationary phase based on CBH I immobilized to silica particles. The best fit of the isothermal titration data corresponded to a 1:1 binding isotherm.
We also recommend Trading Suppliers and Manufacturers of Alprenolol (cas 13655-52-2). Pls Click Website Link as below: cas 13655-52-2 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View