Add time:09/05/2019         Source:sciencedirect.com

The toxicity of tebuthiuron (1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-1,3-dimethylurea) has been studied in several animal species. The acute oral LD50s in mice, rats and rabbits were 579, 644 and 286 mg/kg, respectively. In cats, oral doses of 200 mg/kg were not lethal, while 500 mg/kg given orally did not kill dogs, quail, ducks or chickens. The acute TL50 in fish was > 160ppm.A 3-month study in rats fed diets containing 0, 400, 1000 or 2500 ppm tebuthiuron resulted in moderate growth retardation and a reduction in the efficiency of food utilization in the highest dose group. These changes were evident by wk 1 of the study. In the same group, a non-inflammatory diffuse vacuolization of the pancreatic acinar cell was found. No other important evidence of toxicity occurred. A 3-month study in dogs given daily oral doses of 0, 12·5, 25 or 50 mg tebuthiuron/kg resulted in slight anorexia in all the treated dogs, and a slight body-weight loss in dogs of the highest dose group. There were no other treatment-related signs of toxicity. A 1-month study in chickens fed rations containing 0, 400, 1000 or 2500 ppm tebuthiuron produced, in the highest treatment group, a reduction in food intake and suppression of body-weight gain but no other signs of toxicity. A teratology study produced no significant effects in the offspring of rats fed diets containing 0, 600, 1200 or 1800 ppm tebuthiuron.Skin and eye irritation studies in rabbits and a contact sensitization study in guinea-pigs revealed no remarkable evidence of toxicity.These studies indicate that tebuthiuron has a low order of toxicity in animals.

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