Add time:09/10/2019         Source:sciencedirect.com

The recent developments in the use of natural quinoline products and synthetic quinoline-based molecules as antiparasitic agents for Chagas disease (CD), African sleeping sickness (human African trypanosomiasis, HAT), and leishmaniasis (LE) are reviewed in this chapter. Classical and contemporary syntheses of quinoline derivatives are also discussed, paying attention to new green reaction conditions for classical methods such as Skraup and Friedländer syntheses, Doebner reaction or Povarov reaction, among others. Lipinski’s parameters and in silico study are briefly mentioned and applied to some quinolines active against Leishmania and Trypanosoma parasites. This chapter is focused on medicinal chemistry research with natural and synthetic quinoline molecules as antitrypanosomal agents for these parasitic infections. Carefully selected examples are discussed to underline the progress made in the development of natural and synthetic quinolines for potential therapeutic applications in CD, HAT, and LE.

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