Add time:09/07/2019 Source:sciencedirect.com
Facile one-pot synthesis of 1-substituted-1H-1,2,3,4-tetrazoles 7(a–l) were presented from various aromatic amines, triethyl orthoformate and sodium azide using silver oxide as reusable catalyst and screened for their in vitro antibacterial activity. Compounds 7c (MIC range = 80.30–184.50 µg/mL) and 7i (MIC range = 94.60–179.40 µg/mL) were shown potent antibacterial activity when compared with standard ampicillin (MIC range = 100.00–250.00 µg/mL). In silico ADME parameters were predicted and suggest the potential of 7(a–l) to develop oral drug like candidate.
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