Add time:09/06/2019         Source:sciencedirect.com

Cysteine is one of the more toxic amino acids, however the toxic agent associated with cysteine toxicity has not been identified. Recently it was shown that 2-methyl-2,4-thiazolidine dicarboxylate (cas 16708-09-1) (MTD) was formed from cysteine by rat liver and would be toxic to the rat. This suggested that MTD formed by the rat liver can be produced both enzymatically and by chemical interaction between cysteine and another compound, possibly pyruvate. When MTD (1 mmol/rat) was injected into 6 rats, two of them died. Only 70–80% of the MTD was excreted within 24 h, suggesting an accumulation of MTD. It is possible that MTD could accumulate in the tissues until it reahed a toxic concentration. Whether this could account for the death associated with cysteine toxicity is unknown.

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