Add time:09/06/2019         Source:sciencedirect.com

cis-6-Hexadecenoic acid is a major component of human sebaceous lipids that is involved in skin self-sterilization and atopic dermatitis amelioration. It can be prepared by hydrolysis of isopropyl cis-6-hexadecenoate produced by resting cells of Rhodococcus sp. strain KSM-MT66. To devise an economical industrial-scale process for the production of this rare fatty acid, we optimized the conditions for growing rhodococcal cells. Mg2+ and Fe2+ ions are essential for the efficient production of isopropyl cis-6-hexadecenoate. To further increase the production of isopropyl cis-6-hexadecenoate, we created a mutant strain (T64) with reduced esterase activity by random mutagenesis using UV irradiation of MT66. Under an optimized condition, the mutant T64 produced more than 60 g l−1 isopropyl cis-6-hexadecenoate in a 4-d cultivation, corresponding to about 52 g l−1 cis-6-hexadecenoate.

We also recommend Trading Suppliers and Manufacturers of cis-6-(isopropyl)-3-methylcyclohex-2-en-1-ol (cas 16721-38-3). Pls Click Website Link as below: cas 16721-38-3 suppliers