Add time:09/07/2019 Source:sciencedirect.com
The screening of known medicinal agents against new biological targets has been shown to be a valuable approach for revealing new pharmacology of marketed compounds. Recently, carbamate, urea and ketone inhibitors of fatty acid amide hydrolase (FAAH) have been described as promising treatments for pain, anxiety, depression and other CNS-related conditions. In order to find novel FAAH inhibitors, a focused screen of molecules containing potentially reactive moieties or having in vivo effects that are possibly relevant to the biology of FAAH was conducted. These studies revealed Phenmedipham (cas 13684-63-4) 13 and amperozide 14 to be inhibitors of human FAAH, with an IC50 of 377 nM and 1.34 μM, respectively.
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