Add time:07/15/2019         Source:sciencedirect.com

A fraction, isolated from bovine thymus by sequences of ca. ten steps of extractions, gel filtrations, ion exchange chromatography, etc., stimulated the synthesis of both cAMP and cGMP at a level of 100 μg/ml. Thymone A stimulated cAMP, but is chromatographically remote from the fraction. Essentially pure thymone B, which stimulates cGMP, did not stimulate cAMP even at a high level of 100 μg/ml. The presence of thymone B in this fraction is supported by TLC data. This fraction also stimulated the mixed lymphocyte reaction. The cAMP-stimulating entity is designated thymone C until it is characterized and related to or differentiated from products of other investigators.

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