Add time:09/08/2019 Source:sciencedirect.com
Direct and efficient α-fluorination of amides—which are ubiquitous in natural products, pharmaceuticals, and organic materials—remains a long-standing challenging task. In a recent paper in Nature Chemistry, Maulide and colleagues described a direct and chemoselective nucleophilic α-fluorination of amides by an “umpolung” strategy.
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