Add time:09/07/2019         Source:sciencedirect.com

A panel of three lipid-modified, functionalized biphenyl cross-linkers (fBph) were synthesized and subsequently employed in the preparation of the stapled oxyntomodulin (OXM) analogs. In a luciferase-based reporter assay, these stapled OXM analogs showed varying degree of potency in activating GLP-1R and GCGR, presumably due to the disparate effect of the lipid chains on the local environment close to the ligand-receptor binding interface. In particular, the fBph-1 cross-linked peptide with the lipid chain attached to position-3 of the biphenyl cross-linker exhibited the highest dual agonist activity.

We also recommend Trading Suppliers and Manufacturers of 4,4'-Bis(hydroxymethyl)biphenyl (cas 1667-12-5). Pls Click Website Link as below: cas 1667-12-5 suppliers