Encyclopedia

  • GADOLINIUM BORATE (cas 13709-90-5) and iron oxide bioconjugates: Nanocomposites of next generation with multifunctional applications
  • Add time:09/24/2019         Source:sciencedirect.com

    The systematic investigations concerning the bioconjugation of GdBO3-Fe3O4 nanocomposite and their in vitro biocompatibility with cancer cell lines are reported. The nanocomposites were prepared hydrothermally from magnetite (Fe3O4), borax or boric acid and a Gd3+ salt. Bioconjugation processes were performed with citric acid and fluorescein isothiocyanate-doped silica, followed by the treatment with folic acid. Overall, the procedure involved “bare or PEGylated Fe3O4 as the magnetic core” and “vaterite- or triclinic-type of GdBO3 as the surface borate layer” for comparative evaluation of the results. The successful vectorization of the nanocomposite particles was demonstrated by quantitative and qualitative analytical data. All bioconjugates displayed soft ferromagnetic properties and negative zeta potential values that are appropriate for biological applications. The 10B and 157Gd contents were ca. 1014 atom/μg making them promising agents for BNCT, GdNCT and the combined GdBNCT. The Gd/Fe molar ratios (0.27–0.63) provided the capability for T1- or dual (T1 + T2) magnetic resonance imaging (MRI). In vitro studies were conducted to investigate the efficiency of targeted FA-conjugated versus non-FA conjugated nanoformulations on Mia-Pa-Ca-2, HeLa and A549 cells. Fluorescence microscopy and flow cytometry data unveiled the essential role of the zeta potential competing with folate targeting in the uptake mechanism. The bioconjugated nanoplatforms of GdBO3-Fe3O4 composite, introduced herein, proved to have potential features of next generation agents for magnetically targeted therapy, fluorescence imaging, magnetic resonance imaging/diagnosis and Neutron Capture Therapy.

    We also recommend Trading Suppliers and Manufacturers of GADOLINIUM BORATE (cas 13709-90-5). Pls Click Website Link as below: cas 13709-90-5 suppliers


    Prev:Highly reactive complexes with promising strong magnetic response based on GADOLINIUM BORATE (cas 13709-90-5)s and oxyanions
    Next: Effect of gadolinium on magnetic circular dichroism and electron magnetic resonance of ε-Fe2O3 nanoparticles formed in borate glasses)

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View