Add time:09/08/2019         Source:sciencedirect.com

The synthesis of 4-methoxypropiophenone, an intermediate for the production of fine chemicals and pharmaceuticals, was carried out via Friedel–Crafts acylation of anisole with Propionic anhydride (cas 123-62-6) by using various solid acid catalysts. The reactions were carried out under solvent-free conditions. A novel mesoporous superacid catalyst UDCaT-5 developed in our laboratory was the most active, selective and robust. The conversion of propionic anhydride and selectivity for 4-methoxypropiophenone at an anisole to propionic anhydride mole ratio of 5:1, using UDCaT-5 (0.05 g/cm3) at 383 K were 57% and 98.6%, respectively. The effects of various reaction parameters on the rate of reaction and selectivity were investigated to deduce the intrinsic kinetics of the reaction. Based on the experimental data, a suitable kinetic model was developed and it follows the Eley–Rideal mechanism. The results are novel.

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