Add time:10/01/2019         Source:sciencedirect.com

Protoveratrine was administered orally in 30 hyptertensive patients. These patients were unselected in so far as their age and the probable cause of the hyptertension was concerned. Twenty-five were considered as having essential hypertension, four, chronic glomerulonephritis and one, pheochromocytoma.In 29 patients who tolerated the drug, a significant reduction of the blood pressure to reasonable, often normal, levels was obtained. The drop in blood pressure was observed to be fairly consistent and closely related to the drug dosage.The cardiopulmonary effects consisted of slowing of heart rate and a dramatic relief of acute pulmonary edema. The latter, as suggested by others, may be due to the drop in pulmonary artery and “pulmonary capillary” pressures.The most frequent side-effects were nausea and vomiting, especially in patients prone to develop these manifestations as in those with renal insufficiency or cerebrovascular accident. Psychic disturbances were observed in two cases. Substernal warmth or mild tightness occurred in one case. This is probably a reflex action of the drug, although the possibility of induced angina is not to be overlooked especially when the blood pressure drops rapidly.Oral protoveratrine, administered in the dosage schedules mentioned, appears to be a useful, potent and safe drug treatment of hypertension and hypertensive heart disease.

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