Add time:09/09/2019 Source:sciencedirect.com
Controlled release of hydrocortisone sodium succinate from a device consisting of a drug containing a core of polymethyl methacrylate was achieved by the use of a design incorporating impermeable barriers to drug diffusion and the use of a semipermeable membrane. Initial in vivo study showed sustained intraoral delivery of hydrocortisone sodium succinate during a 6-day period.
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