Add time:07/15/2019         Source:sciencedirect.com

An approach to combine the advantages of random and of focused combinatorial libraries in pharmaceutical research is described with the example of a solid phase synthesis of 2,5-disubstituted thiadiazole ethers. Key steps of synthesis are the introduction of the heterocycle by selective, sequential nucleophilic double substitution of 2,5-bis(methylsulfonyl)-1,3,4-thiadiazole and the oxidation of the benzylsulfanyl-1,3,4-thiadiazole to the corresponding sulfone using MCPBA on solid phase.

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