Add time:09/08/2019         Source:sciencedirect.com

A study of the stereoselective halogenation of 6,6-dimethyl-1-hepten-4-yn-3-ol (1) using a series of halogenating agents is described. Of the many agents investigated, boron trichloride is the most successful reagent for stereoselective halogenation (E:Z=9:1max). The resulting (E)-1-halo-6,6-dimethyl-2-hepten-4-yne (2), a key intermediate for terbinafine, an antifungal agent, is obtained in good yield and stereoselectivity. Two structurally related enyne alcohols have been studied likewise and shown similar versatility.

We also recommend Trading Suppliers and Manufacturers of 1-HEPTEN-4-YNE (cas 19781-78-3). Pls Click Website Link as below: cas 19781-78-3 suppliers