Add time:09/08/2019         Source:sciencedirect.com

Two new taxanes, named wallitaxane G (1) and H (2), were isolated from the roots of Taxus wallichiana (Taxaceae), together with nine known compounds (3−11). Their structures were elucidated on the basis of NMR spectroscopic analysis and the relative configurations of 1 and 2 were determined based on NOESY data. Wallitaxane H (2) showed the most potent α-glucosidase inhibitory activity, with an IC50 value of 16.1 μM. Plausible biosynthetic pathways for the formation of 1 and 2 were proposed based on oxetane ring-opening and benzoyl migration.

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