Add time:09/09/2019         Source:sciencedirect.com

Publisher SummaryStudies on chemical carcinogenesis have three main purposes. First is to elucidate carcinogenic mechanisms, second is to prevent possible carcinogenic hazard due to chemicals in the environment, and third is to provide clinical model systems in experimental animals. Recent studies on chemical carcinogens and mutagens have shown that, with a few exceptions, carcinogens are mutagenic and mutagens are carcinogenic. 4NQO is an example of a compound that has long been known to be both carcinogenic and mutagenic. In many studies, 4NQO has also been used as a positive control substance in mutagenic and carcinogenic experiments. 4NQO has been used in studies on cultured cells in vitro as well as on in vivo carcinogenesis. Very interesting results have been reported on its induction of certain types of gastric carcinomas, pancreatic tumors, and lung tumors that mimic the cases of human tumors. One advantage of using 4NQO as a carcinogen is that metabolic activation systems for it are commonly present in microbial and mammalian cells.

We also recommend Trading Suppliers and Manufacturers of 8-Fluoro-4-nitroquinoline 1-oxide (cas 19789-69-6). Pls Click Website Link as below: cas 19789-69-6 suppliers