Add time:09/26/2019 Source:sciencedirect.com
l-S,R-buthionine sulfoximine (l-S,R BSO) is a potent specific inhibitor of γ-glutamylcysteine synthetase, the rate-limiting step in glutathione (GSH) biosynthesis. GSH is an important component of tumor drug resistance based on a strong association and recent transfection studies. Depletion of intracellular GSH by BSO significantly enhances the cytotoxicity of many cytotoxic agents, principally alkylating agents and platinating compounds but also irradiation and anthracyclines. Phase I clinical trials of BSO+melphalan (l-PAM)have been carried out and observed little toxicity with BSO alone and increased myelosuppression with BSO+l-PAM. Consistent and profound (<10% of control) GSH depletion was observed in serial determinations of tumor GSH levels in patients receiving continuous infusion (CI) BSO. Evidence of clinical activity has been observed in patients with alkylating or platinating agent-refractory tumors. Phase II evaluation of CI BSO with l-PAM is in progress.
We also recommend Trading Suppliers and Manufacturers of L-BUTHIONINE (cas 13073-21-7). Pls Click Website Link as below: cas 13073-21-7 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View