Add time:09/09/2019         Source:sciencedirect.com

SU-12080 and phentolamine reduce the inhibitory responses of the isolated rabbit ileum to epinephrine, norepinephrine and phenylephrine and block the stimulation of the isolated rabbit uterus to these agonists. The drugs are effective in equimolar doses. SU-12080 and phentolamine do not affect the response to, nor are they affected by, isoproterenol. SU-12080 has weak anti-cholinergic, antihistaminic and anti-5-hydroxytryptamine properties. In doses above 0.08 μM, SU-12080 inhibits the pendulum movements of the intestine and reduces its rhythmic contractions. The action is slow in onset and has been related to the potent papaverine-like activity of SU-12080.

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