Add time:09/09/2019         Source:sciencedirect.com

This paper describes enzymatic procedures for the synthesis of (S)-2-amino-4-phenylbutanoic acid ((S)-APBA) and (R)-2-hydroxy-4-phenylbutanoic acid ((R)-HPBA), building blocks of angiotensin converting enzyme inhibitors. 2-Oxo-4-phenylbutanoic acid was converted to (S)-APBA and (R)-HPBA catalyzed by l-phenylalanine dehydrogenase from Rhodococcus sp. M4 and d-lactate dehydrogenase from Leuconostoc mesenteroides, respectively. Both reactions require NADH and the cofactor was regenerated from NAD catalyzed by formate dehydrogenase or glucose dehydrogenase. Studies on the substrate specificity, stability, and substrate inhibition of phenylalanine dehydrogenase and comparison of the two regeneration systems for the synthesis of target molecules are also included.

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