Add time:10/01/2019 Source:sciencedirect.com
Treatment of [1,3,5]triazine-2,4,6-tricarboxylic acid triethyl ester (4) with arylhydrazines provided 5-amino-6-oxo-1,6-dihydro[1,2,4]triazine-3-carboxylic acid ethyl esters 5a–g in moderate to good yields. Hydrolysis under basic conditions gave the corresponding free carboxylic acids 6a–d. Despite the relatively high number of heteroatoms present the amido as-triazine compounds 6a–d showed good solubility in phosphate buffer as determined by a lyophilization solubility assay. Building block 5a served as starting point for the syntheses of two discrete exocyclic 5-amido and 3-amido compound libraries 7 and 8, respectively.
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