Add time:07/15/2019         Source:sciencedirect.com

We disclose a new microwave-assisted protocol for the effective α-arylation of diethyl malonate. The coupling of aryl halides with diethyl malonate proceeds smoothly in short reaction time in the presence of a catalytic amount of Cu(OTf)2, 2-picolinic acid and Cs2CO3 in toluene using microwave irradiation. The resulting α-aryl malonates are then used as key intermediates for synthesis of variety of heterocyclic compounds, including benzodiazepines, isoquinolines and pyrrolopyridine scaffolds.

We also recommend Trading Suppliers and Manufacturers of DIETHYL-2-(TETRAHYDROFURAN-3-YL)MALONATE (cas 949885-88-5). Pls Click Website Link as below: cas 949885-88-5 suppliers