Add time:09/09/2019         Source:sciencedirect.com

The solubility and dissolution thermodynamics of (2Z)-N-cyclohexyl-2-(3-hydroxybenzylidine) hydrazine carbothioamide (CHBH) in various 2-(2-ethoxyethoxy)ethanol + water mixtures from (298.15 to 338.15) K were studied in the present investigation. The solubilities of CHBH were measured using an isothermal method. The experimental solubilities of CHBH were correlated with Apelblat equation and log-linear model of Yalkowsky. The root mean square deviations (RMSD) were observed in the range of (0.41 to 5.34) % and (0.98 to 3.15) % for Apelblat equation and Yalkowsky model, respectively. The correlation coefficients were found to be 0.996 to 0.999 in co-solvent mixtures investigated. The data of RMSD and correlation coefficients indicated good correlation of experimental solubilities with Apelblat and Yalkowsky models. The mole fraction (93.80 × 10− 3 at 298.15 K) and mass fraction solubility (0.21 kg°kg− 1 at 298.15 K) of CHBH were observed highest in pure 2-(2-ethoxyethoxy)ethanol. However, the lowest mole fraction (3.90 × 10− 7 at 298.15 K) and mass fraction solubility (6.00 × 10− 6 kg·kg− 1 at 298.15 K) of CHBH were observed in pure water. Dissolution thermodynamic studies indicated that the dissolution of CHBH was endothermic in all co-solvent mixtures investigated. Based on these results, CHBH has been considered as freely soluble in 2-(2-ethoxyethoxy)ethanol and practically insoluble in water.

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