Add time:09/09/2019         Source:sciencedirect.com

Abroma augusta L. (Malvaceae) leaf is traditionally used to treat inflammatory disorders. In our laboratory, we have scientifically validated the anti-inflammatory effect of A. augusta leaf extract. In this study, it has been aimed to evaluate in vivo anti-inflammatory effect of taraxerol isolated from the methanol extract of A. augusta leaf. It was further intended to find out the probable mechanism of anti-inflammatory effect of taraxerol. The anti-inflammatory effect of taraxerol (5 and 10 mg/kg, i.p.) was measured employing carrageenan-induced paw edema model of acute inflammation. The carrageenan injection resulted significant edema formation in the right paw when compared with un-injected left paw. However, taraxerol (10 mg/kg) treatment could significantly (p < 0.05–0.01) attenuate carrageenan induced paw edema 2 h onward. The effect of taraxerol at the dose of 5 mg/kg was found to be significant (p < 0.05) only after 4 h of carrageenan treatment. Taraxerol (10 mg/kg) treatment could significantly (p < 0.01) attenuate carrageenan mediated up-regulation in the levels of IL 1β, IL 6, IL 12 and TNF α in the right paw tissues. In search of molecular mechanism, taraxerol (10 mg/kg) could significantly (p < 0.05–0.01) reinstate carrageenan provoked NF-κB signaling and thereby caused significant down-regulation in the expressions of COX-2 (p < 0.01) and iNOS (p < 0.05). In conclusion, taraxerol would attenuate acute inflammation via inhibition of NF-κB signaling.

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