Add time:09/26/2019         Source:sciencedirect.com

Ferric dimethyldithiocarbamate (ferbam) and bis(dimethylthiocarbamoyl) disulfide (thiram) are agriculturally important fungicides. The effect of these compounds on development was studied during gametogenesis in rats, organogenesis in rats and mice, and the peri- and postnatal period in rats. Ferbam administered in the diet to rats prior to mating did not affect reproduction in either males after at least 13 weeks of daily doses as high as 109 mg/kg or females after at least 14 days of daily doses as high as 51 mg/kg. Thiram, given during similar periods, produced infertility in male rats at doses of 132 mg/kg and delayed the female estrous cycle at doses of 96 mg/kg. Ferbam administered to rats during organogenesis by gavage at doses of 114 mg/kg reduced the maternal weight gain, litter size, and fetal body weight. Mice survived ferbam treatment during gestation at doses of 228 mg/kg without adverse effects on these parameters. Thiram treatment during organogenesis reduced maternal weight gain and fetal body weight in rats given 40 mg/kg or more. Litter size was decreased in rats given thiram at doses of 136 mg/kg or more. Some mice died at thiram doses of 300 mg/kg; however, development was not affected in the survivors. These fungicides were judged to have little teratogenic activity. The administration of ferbam at 0.15% and thiram at 0.10% of the diet during the peri- and postnatal period reduced the growth and survival of pups. These effects were reversed by cross-fostering. Since ferbam and thiram interfered with reproduction only at doses that produced toxicity in the adult, these compounds were judged to have little primary effect on reproduction.

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