Add time:09/10/2019         Source:sciencedirect.com

Phosphates are ubiquitous in nature and represent a significantly broad field of study within the scientific community given their vital role in biology, biochemistry, pharmaceutical sciences, and synthetic organic chemistry. This chapter will highlight phosphorylation methods through P(V) and P(III) reagents, with an emphasis on recently developed methods. These methods include the diastereoselective synthesis of phosphoramidates, the catalytic condensation of phosphoric acid with alcohols, the Mitsunobu reaction of phosphates as nucleophiles, pyrophosphate formation, enol phosphate generation and their application in metal-catalyzed cross-coupling reactions, thiophosphate and boranophosphate formation, phosphorus–Brook rearrangements, phosphoramidite chemistry and their application in complex molecule synthesis, and H-phosphonates in phosphate synthesis. Catalytic and asymmetric phosphorylation, phosphorothiolate and phosphorothioate oligonucleotide synthesis, phosphate installation in natural product synthesis, and current advances in phosphate protecting groups will also be discussed.

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