Add time:09/25/2019 Source:sciencedirect.com
A series of 2,4,6-trisubstituted pyrimidines and 1,3,5-triazines have been synthesized and screened for their in vitro and in vivo antileishmanial activity against Leishmania donovani. Among all, 14 compounds have shown promising inhibition of 80–100% at 10 μg/ml against promastigotes and IC50 in the range of 0.89–9.68 μg/ml against amastigotes. Three compounds 13, 32 and 33 with good selectivity index (S.I.) were screened for their in vivo activity in golden hamsters (Mesocricetus auratus) infected with MHOM/IN/80/Dd8 strain of L. donovani and have shown moderate in vivo inhibition of 48–56% at a dose of 50 mg/kg × 5, i.p. route for 5 days.
We also recommend Trading Suppliers and Manufacturers of 3-Morpholino-1-(2,4,6-trimethoxyphenyl)-1-propanone (cas 18703-93-0). Pls Click Website Link as below: cas 18703-93-0 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View