Add time:10/01/2019 Source:sciencedirect.com
Titanium tetrachloride mediated dialkylation of acetic anhydride, trifluoroacetic anhydride or difluorochloroacetic anhydride by 1,8-bis(trimethylsilyl)-2,6-octadiene (BISTRO) leads, respectively, to dl-1-methyl-2,5-divinylcyclopentan-1-ol, dl-1-difluoromethyl-2,5-divinylcyclopentan-1-ol or dl-1-trifluoromethyl-2,5-divinylcyclopentan-1-ol. Esterification of these compounds with 4-methoxybenzocyclobutene-1-carboxylic acid and then pyrolysis led to 3-methoxy-12-oxa-17-vinylestra-1,3,5(10)-trien-11-one and to corresponding 18,18-difluoro or 18,18,18-trifluoro derivatives. Further transformations give rise to 3-methoxy-12-oxa-17-(2-oxoethyl)-18,18-difluoroestra-1,3,5(10)-trien-11-one and to the corresponding 18,18,18-trifluoro derivative.
We also recommend Trading Suppliers and Manufacturers of 3-Methoxy-1,3,5(10),9(11)-estratetren-17-one (cas 1670-49-1). Pls Click Website Link as below: cas 1670-49-1 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View