Add time:09/25/2019         Source:sciencedirect.com

A series of methylenealkanes RCH2CH2(R)C = CH2 (R = n-butyl, n-hexyl, isopropyl and isobutyl), which are products of selective zirconocene-catalyzed dimerization of α-olefins, were introduced into Pd-catalyzed methoxycarbonylation. With the use of 5-methyleneundecane (1-hexene dimer) as a substrate, the roles of protic acid, Lewis acid and molecular hydrogen were established for model Pd(II)/PPh3 and Pd(II)/diphosphine catalysts.A series of bridged diphosphines were studied as catalyst components L in PdCl2/L-catalyzed methoxycarbonylation in the presence of H2. One of the nine diphosphines studied, trans-2,3-bis(diphenylphosphinomethyl)norbornane, demonstrated the best catalytic results in terms of catalytic activity, selectivity and isolated yields of the products. Under the optimized conditions during 24 h experiments, dimers RCH2CH2(R)C = CH2 were transformed to methyl carboxylates RCH2CH2(R)CHCH2COOMe with 99+% regioselectivity; isolated yields were 62–81%.In that way, the catalytic methoxycarbonylation of synthetically available methylenealkanes is an effective approach to branched carboxylic acids, with high prospects for practical application.

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