Add time:09/24/2019         Source:sciencedirect.com

Recently, remarkable biological functions have been attributed to nitric oxide (NO) as responsible to mediate neuronal communication, blood vessel modulation, and immune response. The amount of NO seems to be involved in the regulation of cell function and communication suggests that NO precursors could be bound to clinical relevance. This offers potential for NO precursors to be used as a tool for understanding biological functions and also in clinical therapy. Among them, coordination compounds involving nitric oxide derivatives bonded to ruthenium have been postulated as possible metal-based drug. Currently, Brazilian researchers have made notable contributions in this field. Their findings have aided understanding of fundamental features of {Ru–NOx}6 compounds as NO-delivery agents, such as the chemical, thermodynamic, kinetic, photochemical, cytotoxic, and pharmacological properties of these complexes, which will be the focus of this review.

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