Add time:09/24/2019 Source:sciencedirect.com
This article describes the synthesis of a series of butyrophenone analogues in which the propyl chain is partially included in a cyclopentane ring. These trans-(2-aminomethyl)cyclopentyl aryl ketones are obtained by reacting (2-bromomethyl)cyclopentyl phenyl ketone or (2-bromomethyl)cyclopentyl p-fluorophenyl ketone with the corresponding heterocyclic amine. The potential neuroleptic activity of these compounds is reported.
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