Add time:09/27/2019 Source:sciencedirect.com
An asymmetric Diels–Alder reaction between the enantiopure (R)-benzyl-4-(3-acryloyloxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)-benzoate (R)-2 and the N-Z-aminodiene 3 proceeded with total endo diastereoselectivity and was facially controlled in favour of the (3′R,1R,2S)-adduct. The two adducts obtained, 4 (the main compound) and 5, were isolated pure after column chromatography on silica gel. Their LiOH hydrolysis followed by palladium-catalyzed hydrogenation of the double bond concomitant with hydrogenolysis of the carbamate moiety yielded the enantiopure cis-2-aminocyclohexane carboxylic acids (1R,2S)-8 and (1S,2R)-8.
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