Add time:09/26/2019 Source:sciencedirect.com
The catalytic trifluoromethylation of uracil using CF3I was investigated to find a new industrial process for the production of 5-trifluoromethyluracil. The catalytic system of FeSO4, H2O2 and H2SO4 in dimethylsulfoxide efficiently and selectively yielded 5-trifluoromethyluracil under mild conditions. FeSO4 exhibited the highest activity among the Fe(II) compounds tested. H2O2 was indispensable for the reaction and only Fe(II) compounds yielded the desired product. This characteristic of the reaction suggests that it proceeds in a Fenton oxidation manner. The reaction was applicable to large-scale production: 50 kg of 5-trifluoromethyluracil in a 600 L reactor. By the use of this catalytic system, selective trifluoromethylation at the 5-position was also performed with various uracil derivatives including uridines. Interestingly, Cp2Fe was superior to FeSO4 for several substrates.
We also recommend Trading Suppliers and Manufacturers of 5 6-DIHYDRO-5-BROMO-5-METHYL URACIL (cas 1681-77-2). Pls Click Website Link as below: cas 1681-77-2 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View