Add time:07/15/2019         Source:sciencedirect.com

The synthesis, in vitro calcium channel blocking activities and the affinities for the Ca2+-entry receptor protein, of a new series of diethyl 2,6-dimethyl-4-[2-(ω-substituted-alkoxy)phenyl]- -1,4-dihydropyridine-3,5-dicarboxylates are discussed. Increasing the ω-substituted alkoxy chain length from pentoxy to decoxy is found not to affect the calcium channel blocking activity or affinity in both diethyl 4-[2-(ω-aminoalkoxy)phenyl ]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates and diethyl 2,6-dimethyl-4-[2-(ω-thiourea ω-thiouronium substituted-alkoxy)phenyl] -1,4-dihydropyridine-3,5-dicarboxylates.

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