Add time:09/25/2019 Source:sciencedirect.com
New potent histamine H3-receptor antagonists containing an ether group were synthesized from 3-(1H-imidazole-4-yl)propanol and various substituted diphenylmethyl chlorides. Some of the designed ethers showed high activity at histamine H3-receptors under in vitro as well as under in vivo conditions. Their activity at histamine H1- and H2-receptors was also investigated proving a pharmacological H3-H1-antagonistic profile.
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