Add time:07/16/2019         Source:sciencedirect.com

An efficient one-pot synthesis of 3-cyano-4-quinolinone derivatives has been developed via the intramolecular cyclization of cyanoacetylenaminones 1 with N,N-dimethylformamide dimethyl acetal (DMF-DMA) 2 under catalyst-free conditions in CH3CN. The reaction offers several advantages, including operational simpleness, easily available starting materials, target molecular diversity, and facile purification. Additionally, the 3-cyano substituted quinolinones may undergo further functionalization and assist in the discovery of novel drugs.

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