Add time:09/25/2019         Source:sciencedirect.com

5-Iodocytosine exerted a lethal effect in mice in dosages at which the corresponding ribonucleoside, deoxyribonucleoside, or the analogous derivatives of uracil were innocuous. This toxicity was best prevented by the co-administration of 5-methylcytosine, whereas cytosine, cytidine, and deoxycytidine exerted a lesser antidotal activity; in addition, certain halogenated derivatives of uracil exerted some protective activity, whereas uracil and thymine were relatively inert. A marked difference has been observed between the metabolic fates of 5-iodouracil and 5-iodocytosine; catabolism of 5-iodocytosine resulted in higher levels of iodinated acyclic derivatives. Possible schemes for the catabolism of 5-iodocytosine, compatible with the experimental observations, have been discussed.

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