Add time:09/27/2019 Source:sciencedirect.com
The influence of stereochemistry and alkyl side chain length on the bioactivity of the Rho kinase inhibitor Y-27632 [(+)-1, R = Me] was examined by the synthesis of (+)- and (−)-1, and two alkyl chain analogs (+)- and (−)-2 (R = n-propyl) and (−)-3 (R = n-octyl) as well as their evaluation in enzymatic and neurite outgrowth assays.
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