Add time:07/16/2019         Source:sciencedirect.com

Two Schiff bases derived from 3-formylsalicilyc acid have been prepared by conventional condensation with trimethylsilyl-methyl-p-aminobenzoate and trimethylsilyl-propyl-p-aminobenzoate. The compounds were fully characterized by analytical, spectroscopic techniques (FT-IR, 1H-NMR, 13C-NMR, UV–vis and fluorescence) and X-ray diffraction analysis. In the crystal structure the molecular entities are stabilized by intramolecular OH⋯N and OH⋯O hydrogen bonds. 2D supramolecular architectures are formed by self-assembly of the molecules via stacking interactions and by various intermolecular CH⋯OH bonds. Both Schiff bases presented low cytotoxicity in normal human dermal fibroblasts (NHDF) cells showing IC50 values of 127.7 μM for 1 and 63.07 μM for 2 after 24 h of incubation. In vitro antimicrobial tests against three fungi and two bacteria species revealed that both compounds are better inhibitors of fungi species than standard compound Caspoungin.

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