Add time:09/24/2019         Source:sciencedirect.com

desacetamidocolchicine (cas 1420-08-2) (3) and desacetamidoisocolchicine (4) have been chromatographically resolved into enantiomers. Thermal racemization gives inversion barriers of 22.1 and 23.4 kcal mol−1, respectively, for rotation around the bond joining the two aromatic rings. Kinetic binding experiments show that the enantiomer of 3 with the same helicity as native colchicine binds approximately 62 times as fast as colchicine to tubulin whereas the other enantiomer and both enantiomers of 4 do not bind. With molecular mechanics computations both the structures and the rotational barriers are reproduced, provided that the MM2(1985) force field, which gives stiffer aromatic rings than earlier force fields, is used.

We also recommend Trading Suppliers and Manufacturers of desacetamidocolchicine (cas 1420-08-2). Pls Click Website Link as below: cas 1420-08-2 suppliers