Add time:09/29/2019         Source:infona.pl

We have reported that fenfluramine enhancement of 5HT2 neurotransmission impairs frontal motor executive functions. Antagonism of 5HT2 receptors, by improving frontal lobe function, may mediate the beneficial effects of clozapine on negative symptoms. To test this idea, we investigated the effects on neuropsychological, clinical and oculomotor function of a single dose of the 5HT2A/2C antagonist, cyproheptadine (20 mg), in a group of 18 chronic schizophrenic patients, using a double blind placebo controlled crossover design.Cyproheptadine had no effect on any neuropsychological (Stroop, verbal fluency, Wisconsin card sort, Trail making, memory) or clinical measure, although subjects were better than chance in identifying the active drug, indicating adequate absorbtion.Performance on the tests of executive function was correlated with the antisaccade error rate, suggesting the involvement of a common frontal abnormality. The mean antisaccade error rate was 44% and was not influenced by the drug.The results suggest that the impairments in executive and antisaccade eye movement function seen in schizophrenia may reflect a hard wired impairment, which is not modulated by 5HT2A/C receptors. However, it is possible that longer term treatment with this or more selective antagonists might be necessary to release frontal lobe function.

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