Add time:07/16/2019         Source:sciencedirect.com

The asymmetric Michael addition of diethyl malonate and α-substituted diethyl malonates to aromatic nitroalkenes was carried out under mild reaction conditions in a solid–liquid phase transfer reaction in the presence of α-d-glucopyranoside- and α-d-mannopyranoside-based crown ethers as the catalysts. The use of d-glucose-based lariat ether 1 gave the best results. The substituents of the β-nitrostyrene and the diethyl malonate had a significant impact on the chemical yields and enantioselectivity. The addition of diethyl-2-acetamidomalonate to aromatic nitroalkenes afforded the corresponding Michael adducts in moderate to high enantiomeric excess (ee up to 99%). The reaction of diethyl-2-methylmalonate with 2-nitro-β-nitrostyrene gave the adduct with 93% enantiomeric excess in the presence of crown catalyst 1.

We also recommend Trading Suppliers and Manufacturers of DIETHYL 2-(([1-(4-CHLOROPHENYL)-3-METHYL-1H-PYRAZOL-5-YL]AMINO)METHYLENE)MALONATE (cas 956574-60-0). Pls Click Website Link as below: cas 956574-60-0 suppliers