Add time:09/30/2019         Source:infona.pl

Previous research showed that acute exposure to dichloromethane (DCM) produced a selective reduction in peakN 30 of flash evoked potentials (FEPs) in rats. In contrast, acute exposures top-xylene or toluene selectively reduced FEP peakN 160 . The present experiments compared the effects of DCM (logP= 1.25; oil:water partition coefficient), 1,3-dichloropropane (DCP; logP= 2.00), and 1,2-dichlorobenzene (DCB; logP= 3.38) on FEPs recorded from adult Long–Evans rats. Before administration of test compounds, FEPs were recorded for five daily sessions to develop FEP peakN 160 . Test compounds were dissolved in corn oil and administered ip at doses based on proportions of their LD50 values. The doses were: DCM, 0, 57.5, 115, 230, or 460 mg/kg; DCP, 0, 86, 172, 343, or 686 mg/kg; and DCB, 0, 53, 105, 210, or 420 mg/kg. Testing times after dosing varied among compounds and were based on pilot studies to measure both the times of peak effect and recovery. Each solvent produced significant changes in the latency and amplitude of multiple components of the FEP waveforms. However, the predominant effect of DCM was to reduce the amplitude of peakN 30 (ED50 = 326.3 mg/kg), that of DCP was to reduce both peaksN 30 (ED50 = 231.0 mg/kg) andN 160 (ED50 = 136.8 mg/kg), and that of DCB was to reduce peakN 160 (ED50 = 151.6 mg/kg). There was no consistent relationship between logPvalues and the potency of the compounds to alter FEP peaksN 30 andN 160 . The results suggest that organic solvents have multiple acute effects on the function of the central nervous system, which are not predictable solely by the compound's lipid solubility.

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