Add time:07/15/2019         Source:sciencedirect.com

Publisher SummaryThis chapter discusses the physical properties, synthesis, stability, pharmacokinetics and metabolism, and analytical methods of iopanoic acid. Iopanoic acid is an orally administered cholecystographic agent that is rapidly absorbed by the gastroenteric tract and is excreted with bile. The main application of the product is for the diagnosis of bile stones. Nowadays the visualization of bile stones is carried out by ultrasound and oral colecystography is less common. A study of polymorphism of iopanoic acid has shown the existence of two polymorphous forms I and II. I is characteristic of the commercial product, while II has been obtained from a hot benzenic solution of I quickly frozen with a mixture of dry ice and acetone. There is also an amorphous form obtained by the precipitation of iopanoic acid from the aqueous solution of its sodium salt. Metabolism studies following oral and parenteral administration of iopanoic acid to cats, dogs, and humans have shown that the product is excreted in the bile as its glucuronide conjugate.

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